Abi was struggling with his weight before a fluke accident left him mostly paralyzed; bedbound for seven years since then and topping 700 pounds, Abi's only hope for a future with his wife is to get Dr. Now's help to lose weight.

At age 58, Rose had almost given up and eaten herself to death, but it turned out her family needed her too much for her to go; now she has more than 400 pounds to lose if she wants to get healthy for them, and she's determined to do it.

Patrick's weight has never been a bother, but now he's so big that it's getting in the way of his relationship with his daughter; if he wants to see her graduate high school, he'll have to reverse course.

Alyse has been suffering from a burning rash that feels like it's rubbing away her existence; Terry has become too big for his britches due to a painful butt cheek lipoma; James has demons on his back that are ruining his life.

Krystal, a witch, looks to clear a curse of a cyst from her face; Keven wants to get a butt lipoma removed to get his tush back into a regular shape; Raquel, Dr. Lee's esthetician BFF, almost suffocates Dr. Lee with love and a facial.

J-Fab is the life of the party, but her shoulder bump is seriously cramping her style; Dan is a gentle giant with lumps on his head that add a few inches; Teresa's red face and bumpy nose make her feel like a monster.

Fit guy Alonso wants to show off his progress in the gym, but his 70 lipomas are holding him back; Porscha is a comic book enthusiast with two symmetrical lumps on her face; Jeffrey has a leaky lump named Larry on the back of his head.

Robert carries the weight of providing for his family and the weight of the huge lump on his head; Christina has liquid-filled growths next to her eyes; Felipe, a photographer with a dry skin condition so severe he risks losing his career.

Natasha has ambitions of becoming a model, but her massive ear keloids are keeping her off the runway; eight-year-old Wynter wants her scaly mermaid skin cured; Dr. Lee's bestie, Raquel, needs help with a new product for a private area.

Nhan has an extreme, red birthmark that covers half his face; Debbie worries that her shoulder lump will prematurely age her; Justin is a dude rockin' a man bun, but he's having no fun due to the bumps poking through his scalp.

Jess is a widower looking for love who is stuck with a giant bump on his neck; Cherish developed a leopard-print face during pregnancy; former NFL defensive tackle Marcell Dareus hopes Dr. Lee can tackle his forehead lipoma.

Brent has a tricep bump potentially intertwined in his muscle; Jeb loves the beach but refuses to go because of the massive number of blackheads, pimples, and cysts all over his body; Wanda's mysterious mark that caves in her side.

Don's psoriasis has completely taken over his body; Jeff has a large growth on his spine; Sara has an extra set of breasts and nipples.

With pandemic safety protocols in place, Dr. Lee reopens her office; Monica has a large birthmark on the side of her face; Jackie has a melon-sized lump on the back of her shoulder; Reginald has large, rare head growths.

Dr. Lee helps Reginald with the large, rare growths on the back of his head; Che'Re has a prominent bump on her face that has put her in a dark place; Juan has several painful boils on the back of his neck.

Dennis has several giant growths on the back of his head; Juan has a rare condition he hopes Dr. Lee will understand; Natalie searches for answers as to why her body is covered in hundreds of mysterious dark bumps.

With bonus scenes; Audrey pops the painful bumps that cover her body for relief; Felicia has a peculiar looking dark growth on her forehead; Krista's excessive sweating is so severe that on any given day she could fill up a milk jug with her sweat.

With bonus scenes; John fears his neck lump may eventually suffocate him; Shoshana is depressed because of the big growth on her forehead; Ashley hopes Dr. Lee can provide some relief from her three painful skin conditions.

With bonus scenes; Yaellie, a sweet 9-year-old, has itchy psoriasis on over 90% of her body; Matt, a former Marine, has a large, recurring lump in his armpit; twins Tracie and Stacie have numerous matching bumps on their heads.

With bonus scenes; Joanne's forehead growth has held her back from success; Shakisaha split her left earlobe after stretching it with gauges; Mike is a tough guy with a soft bump on his head; Dania's rhinophyma has kept her from enjoying her life.

With bonus scenes; James has a large, squishy forehead lump; Tanisha has an arm growth and itchy scars all over her body; Ed wants his stomach lump removed before his girlfriend gets out of prison.

With bonus scenes; John fears his neck lump may eventually suffocate him; Shoshana is depressed because of the big growth on her forehead; Ashley hopes Dr. Lee can provide some relief from her three painful skin conditions.

With bonus scenes; Yaellie, a sweet 9-year-old, has itchy psoriasis on over 90% of her body; Matt, a former Marine, has a large, recurring lump in his armpit; twins Tracie and Stacie have numerous matching bumps on their heads.

With bonus scenes; Joanne's forehead growth has held her back from success; Shakisaha split her left earlobe after stretching it with gauges; Mike is a tough guy with a soft bump on his head; Dania's rhinophyma has kept her from enjoying her life.

With bonus scenes; James has a large, squishy forehead lump; Tanisha has an arm growth and itchy scars all over her body; Ed wants his stomach lump removed before his girlfriend gets out of prison.

Dennis has several giant growths on the back of his head; Juan has a rare condition he hopes Dr. Lee will understand; Natalie searches for answers as to why her body is covered in hundreds of mysterious dark bumps.

With bonus scenes; Audrey pops the painful bumps that cover her body for relief; Felicia has a peculiar looking dark growth on her forehead; Krista's excessive sweating is so severe that on any given day she could fill up a milk jug with her sweat.

Wanda and Ray are extreme hoarders who face losing their homes and living in isolation if they don't stop surrounding themselves with stuff; filled with anguish, Wanda and Ray know that time is running out.

Hoarding is both a comfort and a curse for two lonely women trying to find the strength to change.

Two women's compulsive hoarding is crowding out their loved ones.

A family of four is on the brink of collapse under the weight of the parents' hoarding; a man denies he's addicted to auctions and garage sales.

Two women seek help for their compulsive hoarding problems.

Joyce's compulsive collecting almost cost her husband his life; Norine's hoarding forced her teenage daughter out of the house.

Jahn is an extreme hoarder trying to clear her two houses before they are both condemned.

A woman and her out of control obsession with bikinis, sweaters and dresses.

A gunman opens fire outside a strip club; a street performer's magic trick goes horribly wrong; BMX superstar T.J. Lavin's routine jump has a shocking outcome.

A shootout leaves a police officer clinging to life; a cowboy and cupid help a she-devil in distress; a zip-line guide falls 80 feet to the canyon floor.

A brutal assault could end a star athlete's career, a 28-year-old man is hit in the head by a flying baseball bat; and a Vegas chef falls asleep with a loaded gun.

A maintenance worker falls from an iconic hotel sign; a rat bite has horrifying implications for its trainer and a plane crashes on a residential street.

Doctors retrieve a stolen Rolex from a very private spot; a pick-up turns deadly when a cabbie is shot multiple times; a dirt-bike accident in the desert leaves a 52-year-old thrill-seeker clinging to life.

Paramedics rescue a 25-year-old man from a burning vehicle; an out-of-control car smashes into the patio of a restaurant; and a Vegas ventriloquist narrowly escapes death in a head-on collision.

A hot time in a hotel room; a couple attempts to have sex in a tree; a woman dislocates her jaw.

A couple's alone time at a pool party gets them busted; a man looking to score medicine; a sticky situation that ends in the emergency room.

A young couple's trip to the grocery store to spice things up; newlyweds with bad luck; a tryst in the shower sends one pair to the emergency room.

A clumsy couple loses something while playing in the bedroom; uncontrollable passion and ice cream; a hot time on the Fourth of July.

A hot time in a hotel room; a couple attempts to have sex in a tree; a woman dislocates her jaw.

A couple's alone time at a pool party gets them busted; a man looking to score medicine; a sticky situation that ends in the emergency room.

A young couple's trip to the grocery store to spice things up; newlyweds with bad luck; a tryst in the shower sends one pair to the emergency room.

A clumsy couple loses something while playing in the bedroom; uncontrollable passion and ice cream; a hot time on the Fourth of July.

Doctors retrieve a stolen Rolex from a very private spot; a pick-up turns deadly when a cabbie is shot multiple times; a dirt-bike accident in the desert leaves a 52-year-old thrill-seeker clinging to life.

Paramedics rescue a 25-year-old man from a burning vehicle; an out-of-control car smashes into the patio of a restaurant; and a Vegas ventriloquist narrowly escapes death in a head-on collision.

Charles replaced one addiction with another when he quit doing hard drugs. Now his BMI is over 100 and he can't stop eating. He needs Dr. Now's help, but with his brother doing everything for him, is he too comfortable to make the trek to Houston?

After gastric bypass surgery, Chad quickly sheds his dangerous weight but faces a medical crisis when he does not follow the doctor's orders.

Brittani married a man who loves large women, but at 600-lbs, she can barely contribute to their marriage, and gets surgery to try to have a normal relationship.

William was always mobile and fairly athletic - that is, until he wasn't; it's been years now since a knee injury derailed his sports career, and he's ballooned up over 600 pounds; now, to lose weight he'll have to face up to how bad it's gotten.

Shakyia was always chubby, but now she does not leave the house and makes no effort; her older sister rallies her to Houston to meet Dr. Now and lose weight, but she is in for a shock when her mother decides that caring for her is just too much.

Dr. Nowzaradan is worried Lupe's emotional issues are blocking her weight loss journey since she's shed over 300-lbs but still can't walk; when Ashley is struck with sudden paralysis, her own emotional stability is thrown into peril.

Surgery enables Teretha to return to family in Detroit, but it soon threatens to undo all her progress; Chad is back on the road, but his old diet is a risk.

Devastated by the sudden loss of her son, Dottie's weight loss journey is in danger of going off track; June embarks on a plan to win approval for skin surgery; Melissa, Jessica and Matt prepare for skin removal surgery.

Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

A number of challenges seem to have cornered Betti Jo and her husband; Susan encounters a serious problem that can throw everything off track.

Mark sets out with a goal for weight-loss surgery, but as weight loss gets easier, he turns down medical advice and decides to do it on his own; Mark thinks he can lose 500 pounds by himself, but Dr. Now sees this as another excuse not to change.

A number of challenges seem to have cornered Betti Jo and her husband; Susan encounters a serious problem that can throw everything off track.

Devastated by the sudden loss of her son, Dottie's weight loss journey is in danger of going off track; June embarks on a plan to win approval for skin surgery; Melissa, Jessica and Matt prepare for skin removal surgery.

After successful sleeve gastrectomy procedures, the Dreier twins collectively lose more than 400 pounds and work toward skin surgeries when a major life event disrupts their world and threatens their progress.

June copes with the tragic death of her son by eating, and must confront the emotional issues driving her food compulsion after gastric bypass surgery.

At 650 pounds, Gideon's weight prohibits him from working, making him completely dependent on his exhausted wife.

Ashley lost over 200 lbs. in Houston, but a family of enablers threatens her progress; Diana has shed 300 lbs., but knee damage may cause her to regain weight.

Ashley hits an emotional wall and is desperate for skin surgery, but she's not losing any weight; after being evicted, Nicole is forced to move back to Ohio, which could impact her weight loss journey.

Brittani has lost over 400 pounds in two years, so she and husband Bill think about expanding their family; Lupe has struggled since surgery, but, having left her husband, may finally start to make the permanent changes she needs.

Milla is dependent on her children and seeks to lose enough weight to be able to walk; Charity is mired in a deep depression, while her daughter, Charly, battles a food addiction; they strive to turn things around and reach their goal weight.

A year since her weight-loss journey began, Janine is still in the 500s and mostly immobile, and now, Dr. Nowzaradan is running out of options for how to treat her if she can't find a way to control her eating habit and start walking again.

Lee's anger issues continue to jeopardize his relationship with Rena and threaten to derail both of their weight-loss journeys; a major life event sends Sarah into a depression that she must pull herself out of if she wants to keep losing weight.

Cynthia, a single mother focused on raising five kids, comes to realize what her death would mean for their future.

Lee's anger issues continue to jeopardize his relationship with Rena and threaten to derail both of their weight-loss journeys; a major life event sends Sarah into a depression that she must pull herself out of if she wants to keep losing weight.

Cynthia, a single mother focused on raising five kids, comes to realize what her death would mean for their future.

A year since her weight-loss journey began, Janine is still in the 500s and mostly immobile, and now, Dr. Nowzaradan is running out of options for how to treat her if she can't find a way to control her eating habit and start walking again.

The CDC, NYPD and FBI team up to deal with anthrax; a mysterious illness targets young girls.

Organ donor recipients share similar symptoms before lapsing into coma; pox outbreak in the Midwest.

A disease that kills 17,000 crows and zoo birds also fills a city's emergency room; an unidentified virus in the Southwest.

A successful businesswoman suddenly seems to become possessed by demons; a young college student battles monstrous pain when she grows fingernails out of her hair follicles.

A mother becomes a recluse when every sound becomes deafeningly loud; a man's career is in jeopardy when he gets drunk without touching a drop of alcohol.

A dad is accused of child abuse when doctors discover his baby has broken bones; a vibrant teenage girl is unable to eat and is wasting away before her mother's eyes.

A woman has seizures whenever she hears her favorite pop tunes; a young athlete loses all his body fat and almost starves to death.

A boy born with no eyes; a separated conjoined twin adjusts to life after losing his twin brother; two brothers suffer from a very rare bone condition; a boy living with a huge facial growth finally gets a diagnosis.

In India, Hemlata Singh, gave birth to a boy with the head and arms of his dead twin attached to his chest; doctors try to save the newborn and separate him from his sibling's body.

A girl's rare disorder causes her eyes to fall out of her head; a man who grows branches from his hands and feet hopes to return home; a baby with a large face tumor.

The world's tiniest brothers find out if they'll ever be able to grow; conjoined twins seek separation surgery; a boy has a rare brain tumor; a girl living with a face tumor embraces her condition.

A woman's arm burns from the inside out; a girl undergoes life-changing surgery to stop her neck from dislocating; a boy has a large facial tumor removed; with bonus content.

A teen sleeps for 10 days.

A woman undergoes a risky craniotomy; a man searches for answers.

A woman and her husband decide to start a family after numerous negative pregnancy tests; a man appears to suffer an embolism.

An infant shows diverse symptoms; an ER nurse gets a diagnosis of lymphoma, before another symptom reveals her true illness.

A woman becomes violently ill after a lifetime of good health.

A woman craves pickles, is extremely fatigued and can barely stay awake during the day.

A woman and her husband decide to start a family after numerous negative pregnancy tests; a man appears to suffer an embolism.

An infant shows diverse symptoms; an ER nurse gets a diagnosis of lymphoma, before another symptom reveals her true illness.

A woman becomes violently ill after a lifetime of good health.

A woman craves pickles, is extremely fatigued and can barely stay awake during the day.

A teen sleeps for 10 days.

A woman undergoes a risky craniotomy; a man searches for answers.

Staff at Houston's Memorial Hermann Emergency Trauma Department treat a teen hit by a truck, a child attacked by a dog and victims of a three-car pileup.

University of New Mexico Hospital staffers treat victims of crime, accident and illness.

Mentally ill son attacks family; horse throws polo-player.

Victims of car crash, scalding, burn.

The staff at Rocky Mountain Regional Trauma Center in Denver treats victims of accidents, violence and illness.

Horseback-riding accident; broken wrist; crash victims.

A woman goes into delivery while in a cab; a life-threatening pregnancy; twin sisters have their babies on the same day.

A cop delivers a baby at a gas station; a woman has a baby six days after learning she's pregnant; a singer gives birth during a talent competition.

A woman gives birth prematurely during Hurricane Sandy; an Army soldier coaches his wife's delivery from Afghanistan; a baby delivered in a shopping mall parking lot.

A baby is born twice; a woman in labor is torn apart by a tornado; a wife gives birth at home.

A best friend's offer to be a surrogate results in a life-threatening pregnancy; a woman is bitten by a deadly snake three weeks before her due date; a cupcake famed for inducing labor.

A grandma-to-be acts as surrogate for her daughter's baby; a very premature baby arrives at a playground; a woman gives birth at home.

A woman believes her neighbors want to kill her; a man is near death after an arrow pierces his chest; two women with swollen abdomens refuse to explain the cause of their pain.

A circus sword-swallower suffers from a persistent case of hiccups; a mother and daughter mysteriously collapse in the ER; a woman loses control of her legs at her daughter's graduation.